huagongshe.com
HRID127197

反应详情

EQUATION

反应方程式

HRID 127197 的结构方程式

REACTANTS

反应物

2
结构：Cc1[nH]cnc1CSCCN
HCID665568

4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole

C7H13N3S

结构：COc1ccc(Cc2cnc(N[N+](=O)[O-])[nH]c2=O)cn1
HCID12783832

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(Cc2cnc(NCCSCc3nc[nH]c3C)[nH]c2=O)cn1
HCID12788664

未命名化合物

收率 63%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

An equimolar mixture of 2-nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone and 2-(5-methyl-4-imidazolyl methylthio)-ethylamine was refluxed in ethanol for 18 hours. The solid which crystallised out on cooling was recrystallised from ethanol to give 2-[2-(5-methyl-4-imidazolyl methylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone, m.p. 197-198.5° in 63% yield.

WORKUP

后处理

  1. customThe solid which crystallised out
  2. temperatureon cooling
  3. customwas recrystallised from ethanol