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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 127199Generated: October 27, 2026

2-Nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone → 2-[2-(2-Thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone

https://huagongshe.com/reaction/127199

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidoneHCID 12783832—
Reactant2-[(Thiazol-2-yl)methylthio]ethylamineHCID 12923403—
SolventEthanolHCID 702—
Product2-[2-(2-Thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidoneHCID 1279955960%

Reaction Steps

An equimolar mixture of 2-nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone and 2-(2-thiazolylmethylthio) ethylamine was refluxed in ethanol for 18 hours. The solid which crystallised out on cooling was recrystallised from ethanol to give 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone, m.p. 95-97° in 60% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04255428
Source datasetuspto-grants-1981_03
ORD IDord-815197395e3d48b4a3ca0850cebfe96f
Source noteuspto-grants-1981_03