HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitroamino-5-(2-methoxy-4-pyridyl)methyl-4-pyrimidone → 2-[2-(3-Bromo-2-pyridylmethylthio)ethylamino]-5-(2-methoxy-4-pyridylmethyl)-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitroamino-5-(2-methoxy-4-pyridyl)methyl-4-pyrimidone | HCID 12783833 | — |
| Reactant | 2-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amine | HCID 12951527 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[2-(3-Bromo-2-pyridylmethylthio)ethylamino]-5-(2-methoxy-4-pyridylmethyl)-4-pyrimidone | HCID 12788675 | — |
Reaction Steps
Reaction of 2-(3-bromo-2-pyridylmethylthio)ethylamine with 1.15 molar equivalents of 2-nitroamino-5-(2-methoxy-4-pyridylmethyl)-4-pyrimidone in refluxing ethanol for 18 hours gave 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(2-methoxy-4-pyridylmethyl)-4-pyrimidone m.p. 70-72° which was boiled under reflux in ethanol containing hydrogen chloride to give 2-[2-(3-bromo-2-pyridylmethylthio) ethylamino]-5-(2-hydroxy-4-pyridylmethyl)-4-pyrimidone trihydrochloride, m.p. 195-198.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255428 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-8a2f7444ab1f4d0a85dcc7436c55a7c4 |
| Source note | uspto-grants-1981_03 |