HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Chloro-4-hydroxy-phenyl)-N-methyl-acetamide → 2-{2-Chloro-4-[2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridin-7-yloxy]-phenyl}-N-methyl-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Chloro-4-hydroxy-phenyl)-N-methyl-acetamide | HCID 18456578 | — |
| Reactant | 7-chloro-2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridine | HCID 22143563 | — |
| Product | 2-{2-Chloro-4-[2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridin-7-yloxy]-phenyl}-N-methyl-acetamide | HCID 18456570 | — |
Reaction Steps
was prepared from coupling of 7-chloro-2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridine and intermediate 63a following Method C. 1H NMR (300 MHz, CD3OD) δ 8.38 (d, 1H, J=5.65 Hz), 7.67 (s, 1H), 7.38 (d, 1H, J=8.48 Hz), 7.27 (d, 1H, J=2.44 Hz), 7.20 (s, 1H), 7.12–7.06 (m, 1H), 6.99 (s, 1H), 6.67 (d, 1H, J=5.47 Hz), 3.91 (s, 3H), 3.61(s, 2H), 2.66 (s, 3H). LCMS (ESI+) [M+H]/z Calc'd 413, found 413. Anal. (C20H17N4O2SCl.0.25CH2Cl2), C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208500B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-192d4ca274ca4395b0766b98cd5162c5 |
| Source note | uspto-grants-2007_04 |