HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Chloro-2-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Chloro-o-anisic acid | HCID 93682 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloro-2-methoxybenzoyl chloride | HCID 22142450 | — |
Reaction Steps
4-Chloro-2-methoxy-benzoic acid (0.50 g, 2.7 mmol) and DMF (50 μl) were added to dichloromethane (9 ml). Oxalyl chloride (0.47 ml, 5.4 mmol) was then added to the mixture and the resultant solution stirred at room temperature for 2 hours. The reaction was monitored to completion by LC-MS. The reaction was concentrated in vacuo to afford crude 4-chloro-2-methoxy-benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208506B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-178314d1507c4374ae811c099d874ca2 |
| Source note | uspto-grants-2007_04 |