反应详情

To a solution of 0.12 g (0.33 mmol) (R)-6-chloro-7-ethoxy-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester in 3 mL dichloromethane 1.5 mL (2.23 g, 19.6 mmol) trifluoroacetic acid was added. After 1 h the volatile components were evaporated and the residue was purified by column chromatography on silica gel (0.030–0.063 mm) with dichloromethane:methanol:ammonia (19:1:0.1) as eluant to give the desired compound as a light yellow solid (89.5%)

1. customAfter 1 h the volatile components were evaporated
2. customthe residue was purified by column chromatography on silica gel (0.030–0.063 mm) with dichloromethane:methanol:ammonia (19:1:0.1) as eluant