(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide → HCID 86596353, compound

HRID 1272115Notes

Reaction equation

HRID 1272115 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:18][C:9]2=[N:10][C:11]([Br:17])=[C:12]([O:14][CH2:15][CH3:16])[CH:13]=[C:8]2[CH:7]=1)=[O:5])[CH3:2].CC(C)([O-])C.[K+].[C:25]([O:29][C:30]([N:32]1[CH2:36][C@H:35]([CH3:37])OS1(=O)=O)=[O:31])([CH3:28])([CH3:27])[CH3:26]>>[CH2:1]([O:3][C:4]([C:6]1[N:18]([C@H:35]([CH3:37])[CH2:36][NH:32][C:30]([O:29][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:31])[C:9]2=[N:10][C:11]([Br:17])=[C:12]([O:14][CH2:15][CH3:16])[CH:13]=[C:8]2[CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 11195739(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxideHCID 23665647Potassium tert-butoxideHCID 73013606HCID 73013606, compound

Product 1

HCID 86596353HCID 86596353, compound

Procedure

This compound was prepared in analogy to example 3, intermediate j) from 6-bromo-5-ethoxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester, potassium tert-butoxide and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-69be7ff8ba1d4ee4a1fd3b032e1f97a5
Source dataset
uspto-grants-2007_04
Patent number
US07208494B2

Reaction notes

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