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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1272136Generated: October 29, 2026

Sodium hydride → (4R,9aR)-7-Cyclopropylmethoxymethyl-6-ethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/1272136

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
ReactantBromomethylcyclopropaneHCID 81503—
Reactant(4R,9aR)-6-ethyl-7-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl esterHCID 69359485—
Product(4R,9aR)-7-Cyclopropylmethoxymethyl-6-ethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl esterHCID 69359814—

Reaction Steps

This compound was prepared in analogy to example 1, intermediate d) from (4R,9aR)-6-ethyl-7-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester, sodium hydride and (bromomethyl)cyclopropane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07208494B2
Source datasetuspto-grants-2007_04
ORD IDord-4e10f99b36c64dfbb661f3742774f068
Source noteuspto-grants-2007_04