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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1272150Generated: November 4, 2026

Diisobutylaluminumhydride → (4R,9aR)-6-Cyclopropylmethoxymethyl-7-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/1272150

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisobutylaluminumhydrideHCID 21225700—
Reactant1H-Pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid, 5-(benzoyloxy)-, 1-(1,1-dimethylethyl) 2-ethyl esterHCID 69356374—
Reactant(4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2,7-dicarboxylic acid 2-tert-butyl ester 7-methyl esterHCID 69361749—
Product(4R,9aR)-6-Cyclopropylmethoxymethyl-7-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl esterHCID 69359857—

Reaction Steps

This compound was prepared in analogy to example 35, intermediate c) from (4R,9aR)-6-cyclopropylmethoxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2,7-dicarboxylic acid 2-tert-butyl ester 7-methyl ester and diisobutylaluminium hydride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07208494B2
Source datasetuspto-grants-2007_04
ORD IDord-25bf81aa189e4b60a5fbf422b523e714
Source noteuspto-grants-2007_04