HCID 69357382, compound → HCID 18455781, compound

Participants

Reaction Steps

A solution of 0.010 g (4R,9aR)-7-fluoro-6-[1-(R)-hydroxy-ethyl]-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester in 1 mL dioxane and 0.1 mL 2M hydrochloric acid was kept at room temperature for 30 min. The solvent was evaporated and the residue was purified by chromatography on silica gel with dichloromethane:methanol:ammonia (100:10:1) to yield 0.005 g 1-(S)-[(4R,9aR)-7-fluoro-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluoren-6-yl]-ethanol as a colorless gum.

Provenance & Evidence