Aluminium lithium hydride → HCID 69360623, compound

HRID 1272180Notes

Reaction equation

HRID 1272180 reaction equation
[CH3:1][C@H:2]1[N:14]2[C:6](=[CH:7][C:8]3[C:13]2=[N:12][CH:11]=[C:10]([CH3:15])[CH:9]=3)[C:5](=O)[NH:4][CH2:3]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][C@H:2]1[N:14]2[C:6](=[CH:7][C:8]3[C:13]2=[N:12][CH:11]=[C:10]([CH3:15])[CH:9]=3)[CH2:5][NH:4][CH2:3]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 69357943HCID 69357943, compound

Product 1

HCID 69360623HCID 69360623, compound

Procedure

This compound was prepared in analogy to Example 3, intermediate l) from (R)-4,7-dimethyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one and lithium aluminium hydride. The product was purified by column chromatography over silica gel (0.030–0.063 mm) with ethyl acetate:methanol (9:1, then 3:1) as eluant.

Workup

  1. customThe product was purified by column chromatography over silica gel (0.030–0.063 mm) with ethyl acetate:methanol (9:1

Sources & evidence

ORD record
ord-c99e05e50f0f4a1e89796448ce524d33
Source dataset
uspto-grants-2007_04
Patent number
US07208494B2

Reaction notes

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