HCID 22723464, compound → HCID 22723455, compound

HRID 1272195Notes

Reaction equation

HRID 1272195 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:16]=[CH:17][O:18][CH:19]=1)C1C=CC=CC=1>ClCCl.[Pd]>[O:18]1[CH:19]=[C:15]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[OH:8])[N:16]=[CH:17]1

Participants

4

Reactant 1

HCID 22723464HCID 22723464, compound

Product 1

HCID 22723455HCID 22723455, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of the oxazole from above (1.99 g, 7.92 mmol) in dichloromethane (20 ml) is added 10% palladium on carbon (1.99 g). The mixture is put under an atmosphere of hydrogen, stirred at room temperature overnight, then filtered through Celite. The solvent is removed under reduced pressure to give 1.15 g of 2-(oxazol-4-yl)phenol (90%).

Workup

  1. filtrationfiltered through Celite
  2. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-8522d758507344c7a2e84cef15d4475e
Source dataset
uspto-grants-2007_04
Patent number
US07208505B2

Reaction notes

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