Sodium Bicarbonate → 2-Fluoro-6-iodophenol

HRID 1272198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1272198
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([I:8])[C:3]=1[O:9]C.C(=O)(O)[O-].[Na+]>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([I:8])[C:3]=1[OH:9]

Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 227234331-Fluoro-3-iodo-2-methoxybenzene

Produkt 1

HCID 222374962-Fluoro-6-iodophenolAusbeute 103,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 2-fluoro-6-iodoanisole (Justus Liebigs, Ann. Chem., 746:134, 1971; 4.31 g, 17.1 mmol) in dichloromethane (35 ml) is added a 1M solution of borontribromide in dichloromethane (18.2 ml). The mixture is kept under argon and stirred for 4 hours at room temperature. The mixture is poured into a saturated aqueous sodium bicarbonate solution and the aqueous layer is extracted with ethyl acetate. The combined organic extracts are dried over sodium sulfate and concentrated under reduced pressure to give 2-fluoro-6-iodophenol (4.2 g).

Aufarbeitung

  1. extractionthe aqueous layer is extracted with ethyl acetate
  2. dry with materialThe combined organic extracts are dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7aae7ab989e2411ba518f92aa7752415
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07208505B2

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