HCID 10140947, compound → HCID 10276170, compound

HRID 1272289Notes

Reaction equation

HRID 1272289 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=O)[N:11]([C:15]3[C:16]([CH3:35])=[C:17]([CH3:34])[C:18]4[O:22][C:21]([CH3:24])([CH3:23])[C@H:20]([C:25]5[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=5)[C:19]=4[C:32]=3[CH3:33])[C:10](=O)[CH2:9]2)=[CH:4][CH:3]=1>CCCCCC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:9][CH2:10][N:11]([C:15]3[C:16]([CH3:35])=[C:17]([CH3:34])[C:18]4[O:22][C:21]([CH3:24])([CH3:23])[C@H:20]([C:25]5[CH:26]=[CH:27][C:28]([CH3:31])=[CH:29][CH:30]=5)[C:19]=4[C:32]=3[CH3:33])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 10140947HCID 10140947, compound

Product 1

HCID 10276170HCID 10276170, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Using (3R)-4-(4-fluorophenyl)-1-(2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl)piperidine-2,6-dione obtained in Example 24, the title compound was synthesized in the same manner as in Example 28. Yield 76%. mp. 141–144° C. (hexane).

Sources & evidence

ORD record
ord-030b902796a44483a98265ab63fc18c0
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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