1-Bromo-4-(trifluoromethoxy)benzene → HCID 58847348, compound

HRID 1272314Notes

Reaction equation

HRID 1272314 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:26][CH2:25][N:24]([C:27]3[C:28]([CH3:41])=[C:29]([CH3:40])[C:30]4[O:34][C:33]([CH3:36])([CH3:35])[C:32](=[O:37])[C:31]=4[C:38]=3[CH3:39])[CH2:23][CH2:22]2)=[CH:17][CH:16]=1>CCCCCC>[F:10][C:9]([F:12])([F:11])[O:8][C:5]1[CH:6]=[CH:7][C:2]([C:32]2([OH:37])[C:31]3[C:38]([CH3:39])=[C:27]([N:24]4[CH2:25][CH2:26][N:21]([C:18]5[CH:19]=[CH:20][C:15]([O:14][CH3:13])=[CH:16][CH:17]=5)[CH2:22][CH2:23]4)[C:28]([CH3:41])=[C:29]([CH3:40])[C:30]=3[O:34][C:33]2([CH3:35])[CH3:36])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 5210081-Bromo-4-(trifluoromethoxy)benzeneHCID 229355955-[4-(4-methoxyphenyl)piperazin-1-yl]-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one

Product 1

HCID 58847348HCID 58847348, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Using 1-bromo-4-(trifluoromethoxy)benzene and 4-(4-methoxyphenyl)-1-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-on-5-yl)piperazine obtained in Reference Example 13, the title compound was synthesized in the same manner as in Example 33. Yield 82%. mp. 175–176° C. (hexane).

Workup

  1. customobtained in Reference Example 13

Sources & evidence

ORD record
ord-1db093bc27954ac2b9816afbfa16c1b8
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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