HCID 58847348, compound → HCID 18456028, compound

HRID 1272316Notes

Reaction equation

HRID 1272316 reaction equation
[F:1][C:2]([F:40])([F:39])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2(O)[C:14]3[C:15]([CH3:35])=[C:16]([N:21]4[CH2:26][CH2:25][N:24]([C:27]5[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=5)[CH2:23][CH2:22]4)[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:37])[CH3:36])=[CH:6][CH:5]=1>C(O)C>[F:40][C:2]([F:1])([F:39])[O:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[C:14]3[C:15]([CH3:35])=[C:16]([N:21]4[CH2:22][CH2:23][N:24]([C:27]5[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=5)[CH2:25][CH2:26]4)[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:36])[CH3:37])=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 58847348HCID 58847348, compound

Product 1

HCID 18456028HCID 18456028, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using 3-(4-(trifluoromethyl)phenyl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Example 65, the title compound was synthesized in the same manner as in Example 46. Yield 70%. mp. 147–148° C. (ethanol).

Sources & evidence

ORD record
ord-d5939c90be74446d90e79c1b7f47b8bf
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

Loading…