Benzene, 1-bromo-4-(trifluoromethyl)- → HCID 58847326, compound

HRID 1272318Notes

Reaction equation

HRID 1272318 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:25][CH2:24][N:23]([C:26]3[C:27]([CH3:40])=[C:28]([CH3:39])[C:29]4[O:33][C:32]([CH3:35])([CH3:34])[C:31](=[O:36])[C:30]=4[C:37]=3[CH3:38])[CH2:22][CH2:21]2)=[CH:16][CH:15]=1>CCCCCC>[F:9][C:8]([F:11])([F:10])[C:5]1[CH:6]=[CH:7][C:2]([C:31]2([OH:36])[C:30]3[C:37]([CH3:38])=[C:26]([N:23]4[CH2:24][CH2:25][N:20]([C:17]5[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=5)[CH2:21][CH2:22]4)[C:27]([CH3:40])=[C:28]([CH3:39])[C:29]=3[O:33][C:32]2([CH3:34])[CH3:35])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 229355955-[4-(4-methoxyphenyl)piperazin-1-yl]-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one

Product 1

HCID 58847326HCID 58847326, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Using 1-bromo-4-(trifluoromethyl)benzene and 4-(4-methoxyphenyl)-1-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-on-5-yl)piperazine obtained in Reference Example 13, the title compound was synthesized in the same manner as in Example 33. Yield 91%. mp. 181–183° C. (hexane).

Workup

  1. customobtained in Reference Example 13

Sources & evidence

ORD record
ord-16da8335f4ba498f9ddd17b23e691340
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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