HCID 58847326, compound → HCID 18456029, compound

HRID 1272319Notes

Reaction equation

HRID 1272319 reaction equation
[F:1][C:2]([F:39])([F:38])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2(O)[C:13]3[C:14]([CH3:34])=[C:15]([N:20]4[CH2:25][CH2:24][N:23]([C:26]5[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=5)[CH2:22][CH2:21]4)[C:16]([CH3:19])=[C:17]([CH3:18])[C:12]=3[O:11][C:10]2([CH3:36])[CH3:35])=[CH:5][CH:4]=1>C(O)C>[F:39][C:2]([F:1])([F:38])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:13]3[C:14]([CH3:34])=[C:15]([N:20]4[CH2:25][CH2:24][N:23]([C:26]5[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=5)[CH2:22][CH2:21]4)[C:16]([CH3:19])=[C:17]([CH3:18])[C:12]=3[O:11][C:10]2([CH3:35])[CH3:36])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 58847326HCID 58847326, compound

Product 1

HCID 18456029HCID 18456029, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using 3-(4-(trifluoromethyl)phenyl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Example 69, the title compound was synthesized in the same manner as in Example 46. Yield 93%. mp. 208–211° C. (ethanol).

Sources & evidence

ORD record
ord-58e6e90f650b48b083ba5d6a9ec40fda
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

Loading…