HRID1272326

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C2CCN(c3c(C)c(C)c4c(c3C)C(O)(c3ccc(C(C)C)cc3)C(C)(C)O4)CC2)cc1OC

HCID58847323

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2CCN(c3c(C)c(C)c4c(c3C)C(c3ccc(C(C)C)cc3)C(C)(C)O4)CC2)cc1OC

HCID18456026

未命名化合物

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21896459

未命名化合物

PROCEDURE

实验过程

Using 3-(4-isopropylphenyl)-5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Example 83, the title compound was synthesized in the same manner as in Example 46. Yield 90%. mp. 129–132° C. (hexane-methanol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1a6063350cbe466cb5bc1f49f6ba0c8a
来源数据集: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07208495B2
来源说明: uspto-grants-2007_04

反应 SMILES

[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2(O)[C:14]3[C:15]([CH3:37])=[C:16]([N:21]4[CH2:26][CH2:25][CH:24]([C:27]5[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=5)[CH2:23][CH2:22]4)[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:39])[CH3:38])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>CCCCCC.CO>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[C:15]([CH3:37])=[C:16]([N:21]4[CH2:22][CH2:23][CH:24]([C:27]5[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=5)[CH2:25][CH2:26]4)[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:39])[CH3:38])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]