3-(4-Isopropylphenyl)-5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol → 1-(3-(4-Isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)-4-(3,4-dimethoxyphenyl)piperidine

HRID 1272326Notes

Reaction equation

HRID 1272326 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2(O)[C:14]3[C:15]([CH3:37])=[C:16]([N:21]4[CH2:26][CH2:25][CH:24]([C:27]5[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=5)[CH2:23][CH2:22]4)[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:39])[CH3:38])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>CCCCCC.CO>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[C:15]([CH3:37])=[C:16]([N:21]4[CH2:22][CH2:23][CH:24]([C:27]5[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([O:35][CH3:36])[CH:28]=5)[CH2:25][CH2:26]4)[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]2([CH3:39])[CH3:38])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 588473233-(4-Isopropylphenyl)-5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol

Product 1

HCID 184560261-(3-(4-Isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)-4-(3,4-dimethoxyphenyl)piperidineYield 90%

Reagents, catalysts & solvents 1

HCID 21896459Hexane methanolSolvent

Procedure

Using 3-(4-isopropylphenyl)-5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Example 83, the title compound was synthesized in the same manner as in Example 46. Yield 90%. mp. 129–132° C. (hexane-methanol).

Sources & evidence

ORD record
ord-1a6063350cbe466cb5bc1f49f6ba0c8a
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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