HRID1272329

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7504

Benzylamine

C7H9N

结构：COc1ccc(C2CCN(c3c(C)c(C)c4c(c3C)C(O)C(C)(C)O4)CC2)cc1OC

HCID67420698

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2CCN(c3c(C)c(C)c4c(c3C)C(NCc3ccccc3)C(C)(C)O4)CC2)cc1OC

HCID58847351

未命名化合物

收率 80%

PROCEDURE

实验过程

Using benzylamine and 5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 19, the title compound was synthesized in the same manner as in Example 57. Yield 80%. Amorphous state powder.

WORKUP

后处理

customobtained in Reference Example 19

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9834647d56044053a8b87789fc9fd0cd
来源数据集: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07208495B2
来源说明: uspto-grants-2007_04

反应 SMILES

[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([CH:19]2[CH2:24][CH2:23][N:22]([C:25]3[C:26]([CH3:39])=[C:27]([CH3:38])[C:28]4[O:32][C:31]([CH3:34])([CH3:33])[CH:30](O)[C:29]=4[C:36]=3[CH3:37])[CH2:21][CH2:20]2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]>>[CH2:1]([NH:8][CH:30]1[C:29]2[C:36]([CH3:37])=[C:25]([N:22]3[CH2:21][CH2:20][CH:19]([C:13]4[CH:14]=[CH:15][C:16]([O:17][CH3:18])=[C:11]([O:10][CH3:9])[CH:12]=4)[CH2:24][CH2:23]3)[C:26]([CH3:39])=[C:27]([CH3:38])[C:28]=2[O:32][C:31]1([CH3:34])[CH3:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1