Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 58847342, compound

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Reaction Steps

Pyridinium p-toluenesulfonate (20 mg, 80 mmol) was added to a solution of 1-(7-(1,3-dioxolan-2-yl)-2,2,4,6-tetramethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl)-4-(4-methoxyphenyl)piperazine (1.41 g, 2.67 mmol) obtained in Example 93 in acetone (15 ml) and water (1 ml) and the mixture was refluxed for 30 minutes. The reaction mixture was concentrated under reduced pressure. The residue was diluted with water and extracted with ethyl acetate. The organic extract was washed with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was crystallized from hexane-ethyl acetate to obtain 1.04 g (yield 81%) of the title compound. mp. 175–177° C.

Provenance & Evidence