HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-fluoropyridine → 3-(6-Fluoropyridine-3-yl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-fluoropyridine | HCID 2783168 | — |
| Reactant | 5-[4-(4-methoxyphenyl)piperazin-1-yl]-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one | HCID 22935595 | — |
| Product | 3-(6-Fluoropyridine-3-yl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol | HCID 58847331 | 67% |
Reaction Steps
Using 4-(4-methoxyphenyl)-1-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-on-5-yl)piperazine and 5-bromo-2-fluoropyridine obtained in Reference Example 13, the title compound was obtained in the same manner as in Example 33. Yield 67% mp. 129–131° C. (hexane-ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208495B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-a15879dd9874455a8fe9c8121c092aa1 |
| Source note | uspto-grants-2007_04 |