Fluorobenzene → HCID 18456071, compound

HRID 1272341Notes

Reaction equation

HRID 1272341 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:8][C:9]1[N:14]=[CH:13][C:12]([CH:15]2[C:19]3[C:20]([CH3:32])=[C:21]([N:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[C:22]([CH3:25])=[C:23]([CH3:24])[C:18]=3[O:17][C:16]2([CH3:34])[CH3:33])=[CH:11][CH:10]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:29]2[CH2:30][CH2:31][N:26]([C:21]3[C:22]([CH3:25])=[C:23]([CH3:24])[C:18]4[O:17][C:16]([CH3:34])([CH3:33])[CH:15]([C:12]5[CH:13]=[N:14][C:9]([F:8])=[CH:10][CH:11]=5)[C:19]=4[C:20]=3[CH3:32])[CH2:27][CH2:28]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10008FluorobenzeneHCID 22935586HCID 22935586, compound

Product 1

HCID 18456071HCID 18456071, compoundYield 50%

Procedure

Using fluorobenzene and 1-(3-(6-fluoropyridine-3-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine obtained in Example 127, the title compound was obtained in the same manner as in Example 16. Yield 50%. Amorphous powder.

Sources & evidence

ORD record
ord-8a12641b0df94bba8ce3c84dea55be35
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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