Hydrochloric Acid → HCID 22935611, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4N hydrogenchloride in ethyl acetate solution (10 ml) was added to a solution of tert butyl 4-(2,2,4,6,7-pentamethyl-3-piperidino-2,3-dihydro-1-benzofuran-5-yl)piperazine carboxylate (1.37 g, 3 mmol) obtained in Example 133 in THF (10 mL)-methanol (10 ml) and the mixture was stirred at 60° C. for 3 hours. After the reaction mixture was cooled to 0° C., the resulting mixture was made weakly alkaline using 1N sodium hydroxide and extracted with ethyl acetate. The organic extract was washed saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified with basic silica gel column chromatography (ethyl acetate) to obtain 0.89 g (yield 83%) of the title compound as an amorphous powder.

Provenance & Evidence