Bromine → HCID 20286562, compound

HRID 127237Notes

Reaction equation

HRID 127237 reaction equation
[Cl:1][CH2:2][C:3]([CH3:16])([CH3:15])[C:4](=[O:14])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[Br:17]Br>C(Cl)(Cl)(Cl)Cl>[Br:17][CH:5]([O:6][C:7]1[CH:8]=[CH:9][C:10]([Cl:13])=[CH:11][CH:12]=1)[C:4](=[O:14])[C:3]([CH3:16])([CH3:15])[CH2:2][Cl:1]

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 201382951-(p-Chlorophenoxy)-3,3-dimethyl-4-chloro-2-butanone

Product 1

HCID 20286562HCID 20286562, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

210 g (0.81 mol) of 4-chloro-1-(4-chlorophenoxy)-3,3-dimethyl-butan-2-one were dissolved in 1,000 ml of carbon tetrachloride. 41 ml (0.81 mol) of bromine were added dropwise at room temperature at a rate such that the bromine was steadily consumed. The mixture was then stirred for 30 minutes at room temperature. After distilling off the solvent in vacuo, 268.3 g (98% of theory) of crude 1-bromo-4-chloro-1-(4-chlorophenoxy)-3,3-dimethyl-butan-2-one were obtained and were directly reacted further.

Workup

  1. customwas steadily consumed
  2. distillationAfter distilling off the solvent in vacuo

Sources & evidence

ORD record
ord-0aa22119f7344c8b838cebce91c030a0
Source dataset
uspto-grants-1981_03
Patent number
US04255434

Reaction notes

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