Dimethyl Ether → HCID 18455681, compound

Participants

Reaction Steps

The product was prepared from N-[2-(1H-Indol-2-yl)-phenyl]-2-(2-methoxy-phenyl)-acetamide. Cleavage of the methylether was accomplished using 1.8 eq of BBr3 (1M solution in dichloromethane) at −78° C. to room temperature (23° C.) and subsequent hydrolysis (32% yield). 96% Purity by HPLC (ELSD), Mass-spec [M+H+]=343, 1H NMR (MeOH-d4): 3.69 s (2H), 6.25 s (1H), 6.71–6.74 m (2H), 7.01–7.07 m (2H), 7.10–7.13 m (2H), 7.22 t, 7 Hz (1H), 7.31–7.36 m (2H), 7.48 d, 8 Hz (1H), 7.52 dd, 8.1 Hz (1H), 8.08 d, 8 Hz (1H).

Provenance & Evidence