Diethyl Ether → 6,7-Bis(3-hydroxyphenyl)-pteridin-4-ylamine methanesulfonate salt

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Reaction Steps

1.308 g (13.63 mmol) of methanesulfonic acid in 10 mL of MeOH was added to the suspension of 2.15 g (6.48 mmol) of 6,7-bis(3-hydroxyphenyl)-pteridin-4-ylamine in 10 mL of MeOH. The mixture became homogeneous and orange-red in color. It was stirred for 30 min and then added dropwise to 400 mL of diethyl ether with vigorous stirring. The formed yellow precipitate was collected, washed with diethyl ether and dried in vacuo to give 2.69 g (97.11% yield) of the product as a light-yellow powder. Mass-spec [ES+]=332.8. 1H NMR (MeOH-d4) 2.70 (3H, s), 6.86–6.90 (2H, m), 6.99–7.01 (2H, m), 7.04–7.08 (2H, m), 7.16–7.21 (2H, m), 8.80 (1H, s).

Provenance & Evidence