Sulfuric Acid → HCID 136358525, compound

Participants

Reaction Steps

1.97 g of 6,7-bis(4-hydroxyphenyl)-pteridin-4-ylamine was added to a solution of 0.585 g of concentrated sulfuric acid in 50 mL of MeOH. The homogeneous mixture was left to stir at ambient temperature for 2 hours, then it was added dropwise to 400 mL of diethyl ether. The formed orange precipitate was collected, washed repeatedly with ether and dried in vacuo to give 2.36 g (92.5% yield) of the product as a light-orange fluffy powder. 100% purity by LC/MS (230 DAD). Mass-spec [ES+]=332.8. 1H NMR (MeOH-d4) 6.77–6.80 (4H, m), 7.48–7.53 (4H, m), 8.73 (1H, s). 1H NMR (DMSO-d6) 6.76–6.81 (4H, dd), 7.41–7.47 (4H, dd), 8.84 (1H, s), 9.85 (1H, s), 10.01 (1H, s), 9.94 (1H, br.s), 10.15 (1H, br.s).

Provenance & Evidence