Sodium Bicarbonate → HCID 135485500, compound

Participants

Reaction Steps

105.0 mg (0.253 mmol) of 6,7-bis(3,4-dihydroxyphenyl)-pteridine-2,4-diamine dihydrochloride salt was dissolved in 3 mL of water and 42.53 mg of solid NaHCO3 was added to this solution. The reaction mixture was stirred for 30 min. A slurry of yellow precipitate was formed, it was centrifuged down and solvent was decanted. The dark-yellow residue was dissolved in 3 mL of MeOH and added dropwise to 40 mL of diethyl ether. The formed yellow precipitate was collected, washed with ether and dried in vacuo to give 92.5 mg (96.5% yield) of the product as a yellow, fluffy powder. 97% purity by LC/MS (230 DAD). Mass-spec [M+H+]=379.3. 1H NMR (MeOH-d4) 6.68–6.73 (2H, dd), 6.79–6.81 (1H, dd), 6.84–6.86 (1H, dd), 6.93 (1H, d), 7.03 (1H, d).

Provenance & Evidence