関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bicarbonate Ion | HCID 769 | — |
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | 6-(Bromomethyl)-2-imino-2,3-dihydropteridin-4-amine--hydrogen bromide (1/1) | HCID 12503242 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 6-(Benzylamino-methyl)-2,4-pteridinediamine | HCID 18455747 | 62% |
反応手順
To a solution of 6-bromomethyl-2,4-pteridinediamine hydrobromide (35.7 mg, 0.106 mmol) in anhydrous N,N dimethylacetamide was added benzylamine (28.6 ul, 0.212 mmol). The reaction mixture was stirred at 50° C. overnight. The crude product was poured into saturated bicarbonate solution. The resulted precipitate was collected and purified by preparative HPLC. 17.7 mg product was obtained. Yield: 62%; 1H NMR (500 MHz, DMSO-d6): δ 4.30499(s, 2H), 4.51599(s, 2H), 7.42787–7.47298(m, 3H), 7.50007–7.51927 (m, 2H), 8.87751(s, 1H); ESI-MS: m/z 282 (M++1)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07208493B2 |
|---|
| 出典データセット | uspto-grants-2007_04 |
|---|
| ORD ID | ord-9c0e5e93276546f39777a4f3fceafa60 |
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| 出典メモ | uspto-grants-2007_04 |
|---|
