HRID127249

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69716

Benzene, 1-(chloromethyl)-3-(trifluoromethyl)-

C8H6ClF3

HCID13037790

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCOCC(O)CN1CCN(Cc2cccc(C(F)(F)F)c2)CC1

HCID13037796

未命名化合物

PROCEDURE

实验过程

Following the procedure of Example 5, 1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine was reacted with 3-(trifluoromethyl)benzyl chloride to form 1-(3-trifluoromethylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)piperazine, mp 133°-135° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4c3209023b76405cace4f52bfb4581c5
来源数据集: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04255426
来源说明: uspto-grants-1981_03

反应 SMILES

[OH:1][CH:2]([CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[F:28][C:29]([F:39])([F:38])[C:30]1[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=1)[CH2:33]Cl>>[F:28][C:29]([F:38])([F:39])[C:30]1[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=1)[CH2:33][N:7]1[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:5][CH2:6]1