Sulfamic Acid → HCID 18455744, compound

HRID 1272501Notes

Reaction equation

HRID 1272501 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]3[C:14](=[N:15][C:16]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:13]=[CH:12][N:11]=[C:10]3[NH2:23])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)N.N[CH2:30][CH2:31][CH2:32][N:33]1[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]1>>[C:1]1([C:7]2[N:8]=[C:9]3[C:14](=[N:15][C:16]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:13]=[CH:12][N:11]=[C:10]3[NH:23][CH2:30][CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 5987Sulfamic AcidHCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 21792987HCID 21792987, compound

Product 1

HCID 18455744HCID 18455744, compoundYield 17%

Procedure

6,7-Diphenyl-pteridin-4-ylamine (200 mg, 0.669 mmol) and sulfamic acid (300 mg, 1.91 mmol) were dissolved in 4 ml 1-(3-aminopropyl)-4-methylpiperazine. The mixture was reflux for overnight. Preparative HPLC was used to isolated the product. 50 mg (6,7-Diphenyl-pteridin-4-yl)-(3-(4-methyl-piperazin-1-yl)-propyl)-amine was obtained. Yield: 17%, ESI-MS: [M+H]+, 441

Workup

  1. temperatureThe mixture was reflux for overnight
  2. customto isolated the product

Sources & evidence

ORD record
ord-de3914bf1d2c4558a3d41890df42a68a
Source dataset
uspto-grants-2007_04
Patent number
US07208493B2

Reaction notes

Loading…