Methyl iodide → Methyl 6-bromopyridine-2-carboxylate

Participants

Reaction Steps

Treat 6-bromopicolinic acid (1.99 g) in DMF (10 mL) with potassium carbonate (1.40 g) and then methyl iodide (4 mL) at room temperature for 20 h. Dilute the reaction mixture with dichloromethane (60 mL) and filter. Extract the filtrate with brine (twice), dry (MgSO4), and concentrate in vacuo to give methyl 6-Bromopicolinate pale yellow solid (1.75 g).

Provenance & Evidence