Diisopropylethylamine → Benzyl (2S)-3-(2-bromophenyl)-2-{[(2R)-2-bromopropanoyl]amino}-propanoate

Participants

Reaction Steps

Introduce 25.7 g of benzyl (S)-2-bromophenylalaninate and 150 ml of dichloromethane into a reactor, then bring the temperature of the reaction mixture to 0° C. and add 20 ml of diisopropylethylamine followed by 13.2 g of (2R)-2-bromopropionyl chloride. Subsequently, bring the mixture to ambient temperature. After stirring for 1 hour at that temperature, wash the mixture with water and then with dilute acetic acid solution, and evaporate off the solvents to yield the title compound.

Provenance & Evidence