Fluticasone → Fluticasone Propionate

Participants

Reaction Steps

The crude fluticasone (10 g) is dissolved in 1-butanol (200 ml) at 115–120° C. Gradually cool to ambient temperature and stirred for 1 hr. The crystallized product is filtered and washed with 1-butanol (10 ml). Dried at 60–62° C. to obtain pure fluticasone propionate (recovery 8.5 g, purity 99.40%).

Provenance & Evidence