1-Octanol → Octanal

Participants

Reaction Steps

1-Octanol (2.0 g, 15.4 mmol), sodium acetate (1.8 g, 21.6 mmol), 4-hydroxy TEMPO (53 mg, 0.31 mmol) and dichloromethane (15 ml) were put in a 50-ml egg plant type flask. The suspension was cooled to less than 10° C. in an ice bath, and thereto was added NBA (2.5 g, 18.5 mmol)divided in two portions. The insoluble materials were filtered off and the filtrate was washed with 5% aqueous sodium bicarbonate solution. The crude product was purified by distillation to give 1-octanal (1.78 g, yield 90%).

Provenance & Evidence