HCID 13016597, compound → HCID 10377263, compound

HRID 127260Notes

Reaction equation

HRID 127260 reaction equation
[CH2:1]([N:8]1[CH2:12][C:11]2([CH2:17][CH2:16][N:15](C(OCC3C=CC=CC=3)=O)[CH2:14][CH2:13]2)[O:10][C:9]1=[O:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd].C(O)C>[CH2:1]([N:8]1[CH2:12][C:11]2([CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[O:10][C:9]1=[O:28])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 13016597HCID 13016597, compound

Product 1

HCID 10377263HCID 10377263, compoundYield 107.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 22.2 g 3-benzyl-8-carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one, 150 ml ethanol and 5 g, 5% palladium on barium sulfate is hydrogenated at 60 psi at room temperature for 90 minutes. After filtration and removal of solvent there is obtained 15.4 g of 3-benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 69°-71°.

Workup

  1. filtrationAfter filtration and removal of solvent

Sources & evidence

ORD record
ord-6b04222686344bb6aec514f81d68589a
Source dataset
uspto-grants-1981_03
Patent number
US04255432

Reaction notes

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