Benzylamine → HCID 21923050, compound

HRID 1272616Notes

Reaction equation

HRID 1272616 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4]([NH:24][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 21923063HCID 21923063, compound

Product 1

HCID 21923050HCID 21923050, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
95 °C

Procedure

139 mg of the product obtained in Stage 1 above, 2 ml of butanol and 0.06 ml of benzylamine are mixed together and the reaction medium is heated to a temperature of approximately 95° C. for 5 hours 30. The reaction medium is then left to return to ambient temperature and to crystallize, followed by separating, washing with 10 ml of isopropanol and drying under vacuum at approximately 50° C. In this way 157 mg of expected product is obtained in the form of white crystals.

Workup

  1. waitThe reaction medium is then left
  2. customto return to ambient temperature
  3. customto crystallize
  4. customby separating
  5. washwashing with 10 ml of isopropanol
  6. customdrying under vacuum at approximately 50° C

Sources & evidence

ORD record
ord-b91dd937914242888683042ecdfe3d31
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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