Benzylamine → HCID 21922954, compound

HRID 1272618Notes

Reaction equation

HRID 1272618 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[C:4](Cl)[N:3]=1.[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[C:4]([NH:24][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 21923086HCID 21923086, compound

Product 1

HCID 21922954HCID 21922954, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
100 °C

Procedure

191 mg of the product obtained in Stage 1 above, 2.5 ml of butanol and 0.115 ml of benzylamine are mixed together and the reaction medium is heated to a temperature of approximately 90 to 110° C. for 5 hours. The reaction medium is then left to return to ambient temperature and left to crystallize, followed by separating, washing with 10 ml of isopropanol and drying under vacuum at approximately 50° C. In this way 148 mg of expected product is obtained in the form of white crystals.

Workup

  1. waitThe reaction medium is then left
  2. customto return to ambient temperature
  3. waitleft
  4. customto crystallize
  5. customby separating
  6. washwashing with 10 ml of isopropanol
  7. customdrying under vacuum at approximately 50° C

Sources & evidence

ORD record
ord-1d01da59e61e44b4b32e6f0dd4c611eb
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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