Aniline → HCID 21923032, compound

HRID 1272638Notes

Reaction equation

HRID 1272638 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:3]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 21923063HCID 21923063, compound

Product 1

HCID 21923032HCID 21923032, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The operation is carried out as in Stage 2 of Example 2 from 200 mg (0.77 mM) of the product obtained in Stage 1 of Example 2 and 3 ml of butanol and using 0.088 ml of aniline (0.96 mmole) in place of the benzylamine. In this way 213 mg of expected product is obtained in the form of white crystals.

Sources & evidence

ORD record
ord-007301d98a9041c4b07cda55ff71090f
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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