HCID 21923032, compound → HCID 18457587, compound

HRID 1272639Notes

Reaction equation

HRID 1272639 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:3]=1.[NH2:23][C@H:24]1[CH2:29][CH2:28][C@H:27]([NH2:30])[CH2:26][CH2:25]1>>[ClH:1].[ClH:1].[NH2:23][CH:24]1[CH2:29][CH2:28][CH:27]([NH:30][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][N:8]3[CH:11]3[CH2:15][CH2:14][O:13][CH2:12]3)=[C:4]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:3]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 21923032HCID 21923032, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 18457587HCID 18457587, compoundYield 115.6%

Procedure

The operation is carried out as in Stage 3 of Example 2 starting from 198 mg of the product obtained in Stage 1 above and 716 mg of trans-1,4-diaminocyclohexane. After purification on silica eluting with methanol/ammonium hydroxide (NH4OH) in a proportion of 98/2 and salification with 1.4 N hydrochloric acid in ethanol, 169 mg of expected product is obtained in the form of pink beige crystals

Workup

  1. customAfter purification on silica eluting with methanol/ammonium hydroxide (NH4OH) in a proportion of 98/2 and salification with 1.4 N hydrochloric acid in ethanol

Sources & evidence

ORD record
ord-cddaaf082c3a47f2b9443a249cbac2cb
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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