HCID 21923017, compound → HCID 18457567, compound

HRID 1272654Notes

Reaction equation

HRID 1272654 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[NH2:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]1>>[ClH:1].[ClH:1].[NH2:19][CH:20]1[CH2:25][CH2:24][CH:23]([NH:26][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][N:8]3[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][CH2:16][CH2:17][CH3:18])[N:3]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 21923017HCID 21923017, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 18457567HCID 18457567, compoundYield 87.5%

Procedure

The operation is carried out as in Stage 2 of Example 44 starting from 117 mg of the product obtained in Stage 1 above and 500 mg of trans-1,4-diaminocyclohexane. In this way 80 mg of expected product is obtained in the form of crystals.

Sources & evidence

ORD record
ord-7e7633e236e842dcb73610d792e5c890
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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