HCID 21923072, compound → HCID 18457563, compound

HRID 1272656Notes

Reaction equation

HRID 1272656 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=2)[N:3]=1.[NH2:27][C@H:28]1[CH2:33][CH2:32][C@H:31]([NH2:34])[CH2:30][CH2:29]1>>[ClH:1].[ClH:1].[NH2:27][CH:28]1[CH2:33][CH2:32][CH:31]([NH:34][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][N:8]3[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[N:3]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 21923072HCID 21923072, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 18457563HCID 18457563, compoundYield 99.5%

Procedure

The operation is carried out as in Stage 2 of Example 44 starting from 201 mg of the product obtained in Stage 1 above and 595 mg of trans-1,4-diaminocyclohexane. In this way 139 mg of expected product is obtained in the form of crystals.

Sources & evidence

ORD record
ord-d6e193c0ed8546c5969838e6490f1a86
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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