HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 3-Methyl-8-benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-Benzyl-4-((methylamino)methyl)piperidin-4-ol | HCID 18351329 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Methyl-8-benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one | HCID 20286490 | — |
Reaction Steps
A solution of 23 g 1-benzyl-4-hydroxy-4-methylaminomethylpiperidine and 250 ml dichloromethane is mixed with 100 ml of a 15% solution of phosgene in toluene. Evaporation of solvent gives a residue which is treated with 300 ml dichloromethane and 300 ml aqueous sodium bicarbonate. Separation of the dichloromethane layer followed by evaporation gives 20 g 3-methyl-8-benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 137°-138°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255432 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-0372e8c34f9c4ccdb644b6a7d2498417 |
| Source note | uspto-grants-1981_03 |