HCID 21922938, compound → HCID 178478726, compound

Participants

Reaction Conditions

Reaction Steps

342 mg of trans-1,4-diaminocyclohexane is taken to approximately 150° C. then 234 mg of the product obtained in Stage 1 above is added, the reaction medium is maintained under agitation at 140° C. for 9 hours 30 minutes then left to return to ambient temperature. Then 10 ml of water is added, followed by extracting with dichloromethane, drying and evaporating the solvent. The residue is chromatographed on silica (eluent: MeOH/NH4OH 98/2), followed by taking up in 5 ml of an ethanolic solution of hydrochloric acid, evaporating the solvents, impasting the residue in ether and drying under reduced pressure at 60° C. 93 mg of expected product is recovered.

Provenance & Evidence