HCID 21923033, compound → HCID 178478740, compound

Participants

Reaction Conditions

Reaction Steps

360 mg of the product obtained in Stage 1 above and 450 mg of trans-1,4-diaminocyclohexane are mixed together and the reaction medium is heated to approximately 140° C. for 6 hours. After evaporating the solvent, chromatography on silica is carried out (eluent methylene chloride/ methanol/ammonium hydroxide 85/15/1.5) followed by taking up in an ethanolic solution of hydrochloric acid, leaving to crystallize, separating, drying under reduced pressure and 280 mg of expected product is recovered.

Provenance & Evidence