反应详情

温度

140 °C

247 mg of the product obtained in Stage 1 above and 350 mg of trans-1,4-diaminocyclohexane are mixed together and the reaction medium is heated to 140° C. for 6 hours. After evaporating the solvent, chromatography on silica is carried out (eluent methylene chloride/methanol/ammonium hydroxide 85/15/1.5) followed by taking up in an ethanolic solution of hydrochloric acid, leaving to crystallize, separating, drying under reduced pressure and 130 mg of expected product is recovered.

1. customAfter evaporating the solvent, chromatography on silica
2. customleaving
3. customto crystallize
4. customseparating
5. dry with materialdrying under reduced pressure and 130 mg of expected product
6. customis recovered