Methanol → HCID 178478731, compound

Participants

Reaction Steps

400 mg of trans-1,4-diaminocyclohexane is taken to approximately 150° C. then 333 mg of the product obtained in Stage 1 above is added, the reaction medium is left under agitation for 3 hours then left to return to ambient temperature and diluted with 30 ml of dichloromethane. 10 ml of methanol is added, followed by washing with 10 ml of water, drying and evaporating the solvents. Chromatography on silica is carried out (eluent: MeOH/NH4OH 98/2), the residue is taken up in an ethanolic solution of hydrochloric acid, followed by evaporating the solvents, impasting in ether, separating, drying under reduced pressure at ambient temperature and 66 mg of expected product is recovered.

Provenance & Evidence