HRID1272688

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=[C](C)[Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC

HCID10871254

2-(Tributylstannyl)propene

C15H32Sn

结构：COC(=O)[C@@H](Cc1ccc(Br)s1)NC(=O)OC(C)(C)C

HCID68972961

未命名化合物

PRODUCTS

生成物

结构：C=C(C)c1ccc(C[C@@H](NC(=O)OC(C)(C)C)C(=O)OC)s1

HCID68972732

未命名化合物

收率 63.4%

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

PROCEDURE

实验过程

15.0 g (41.17 mmol) of 3-(5-bromo-thiophen-2-yl)-2(R)-tert-butoxycarbonylamino-propionic acid methyl ester was treated with tributyl-isopropenyl-stannane (17.88 g, 54.07 mmol) and Pd(PPh3)4 (4.8 g, 4.15 mmol) as described in the general procedure M to afford 8.50 g of 2(R)-tert-butoxycarbonylamino-3-(5-isopropenyl-thiophen-2-yl)-propionic acid methyl ester.