HCID 68973677, compound → HCID 11956452, compound

Participants

Reaction Steps

The title compound was prepared by the treatment of 2(S)-{[7-(4-tert-Butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]-amino}-3-(5-isopropenylthiophen-2-yl)-propionic acid methyl ester (prepared in Example 29) with Pd/C and H2 gas (1 atm) by the general procedure N to afford 2(S)-{[7-(4-tert-Butyl-phenoxy)-1-cyclopentylmethyl-1-isoquinoline-3-carbonyl]-amino}-3-(5-isopropylthiophen-2-yl)-propionic acid methyl ester. This ester was hydrolyzed by the general procedure C to afford the title compound.

Provenance & Evidence